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I guess the will work, but to be sure I'll ask someone at MSI if there are any known issues.Unfortunately, there is not any word about the compatibility of 48GB modules, however, in numerous articles as well as in the specifications (https://www.msi.com/Motherboard/PRO-Z790-P-WIFI/Specification) it is mentioned that the 192GB of DDR5 RAM is supported. citation: "4x DDR5, Maximum Memory Capacity 192GB"